Villains In The Powerpuff Girls Z

Mojo Jojo 

An ordinary zoo monkey who was made fun of by people and decided to seek revenge on humanity after the ray from Chemical Z made him intelligent. He is physically more powerful than the original version of the character, able to fly and lay a dozen punches at one time. This version of Mojo frequently displays an immature attitude and makes the most childish flaws throughout his plans. While the original Mojo was portrayed as one of the most competent and genuinely threatening villains in the series, the anime version is more of a rather inept comic relief and is seen by the Powerpuff Girls Z as more of an annoying nuisance than a dangerous enemy. The anime Mojo also does not repeat himself redundantly as the original Mojo does, he ends most of his sentences with saying his name. He is the same size as the original, as the giant cape conceals his small figure.

Him 

Him is the most powerful enemy of the series, and it is safe to say that he is the main antagonist. Him is a demon saved, nothing more and nothing less than chaos itself. His biggest weakness is the cold. In ancient times, Him was dedicated to bring about the destruction of a small town, however, was defeated by the Great Edo ChakiChaki Girls who took advantage of Him's weakness which is cold or snow to lock him up and take part of their evil and save the mountains. But when Ken ended up destroying one of the icebergs in the bay of New Townsville, black lights were scattered all around New Townsville consequently, over producing and giving birth to the many villains in the city and a black light struck Him and woke him. It is also known that he releases a strange dust that was responsible for producing some villains.

Fuzzy Lumpkins 

In Powerpuff Girls Z, it is unknown who or what he was before being hit by the black light. Fuzzy looks almost exactly the same as his original counterpart: a large pink creature in overalls. This rendition of Fuzzy is as rude and destructive as the original, but is nice enough to help an old man or sign an autograph for a fan who likes his banjo playing, that is before going on a rampage. Like Mojo Jojo, he ends most of his sentences with "de mon da". He has a crush on Ms. Bellum.

Himeko Shirogane 

Himeko is a bratty rich kid in the girls' class who is hit by the black light. Her powers are used based on her wants to be recognized by people. Once she is back to normal however, she does not recall any events that occurred while she was evil. She has a strong dislike for Momoko, Miyako and Kaoru, trying to get them into trouble even when she is not evil. She does, however, have some odd feeling of friendship toward them that she displays from time to time. She has an older sister named Miko, who does everything better than her, and even draws attention by their parents. However, while she is somewhat jealous of Miko, she loves her sister very much and is always excited when she visits. Unlike the original cartoon series, both of her parents' faces are shown and her mother is alive and around. She has a cat named Sapphire, whose scream causes Himeko' transformation turning to Princess.

The Gangreen Gang 

The Gangreen Gang are remotely similar to the ones in the American version, with the exception of Weevil and Ivy being girls, and how Ace lost his New York accent entirely. Unlike Lil' Arturo, Weevil does not have a Mexican accent. Also, everyone has different names: Bobby Green (Ace), Ivy (Snake), Weevil (Lil' Arturo), Lunk (Grubber), and Big Boy (Big Billy.)

The Amoeba Boys 

A group of amoeba brought to life by the black light. Their members are Silk Hat, Poncho and Lady, who is actually a girl.

Sakurako Kintoki 

Sakurako is a shy girl who runs a candy store. She has a crush on a boy named Souichiro and it is her jealousy towards him that leads her to be hit by the black lights, transforming her into Sedusa whenever she puts on some lipstick. As Sedusa, Sakurako can wear makeup to make herself look like anyone, as well as use her hair like tentacles, traits shared with her American counterpart, but unlike her American counterpart, Annie, as well as Sedusa, is in love with Souichiro, a regular client of her shop, rather than Professor Utonium.

Rowdyruff Boys Z 

Brick, Boomer and Butch are created by Mojo based on the DNA found on the girls' personal items. These items form the basis of the Rowdyruff's weapons. Brick's weapon is actually Hyper Blossom's heart twisty straw, which he shoots spits fireballs at the girls, Boomer's weapon is Rolling Bubbles' used cotton bud used his own ear wax at opponents and Butch's weapon is Powred Buttercup's smelly gym sock which he would throw like a boomerang.

Michel
Michel, also known by his alter ego Gigi the Great, is an effeminate hairdresser with strange tastes in hair. He has a teddy bear that when wound up, compliments Michel and tells him that he's great. The teddy bear gets hit by the black light and grants Michel powers of hypnosis to make the customers to accept his eccentric hairstyle. The cause of his transformation is hearing compliments from the teddy bear, and to prevent any further transformations, Ken and the Powerpuff Girls Z replace the old recording on the teddy bear with a new one that insults Michel.

Miko Shirogane
Himeko's older sister who always likes to stand out, which is often the cause of grief for her younger sister, although the two do care for each other. When she gets jealous of the Powerpuff Girls' fame, she has a suit developed that temporarily gives her powers exceeding the girls, naming her Shirogane Z in order to upstage them.